Cushing’s disease was first described as ‘polyglandular syndrome’ by Harvey Cushing in 1932.¹ He called the condition ‘pituitary basophilism’. It represents the chronic exposure of tissue to increased plasma cortisol and causes a group of symptoms and signs that is called Cushing’s syndrome. Cushing’s syndrome is generally defined as pathological hypercortisolaemia.

There are several conditions that can cause this syndrome, including pituitary adenoma (Cushing’s disease),Elevator Casual Shoes ectopic ACTH secretion, adrenal tumours, ectopic secretion of corticotrophin- releasing hormone, severe depression and chronic glucocorticoid treatment. Ideally, the physician should be able to determine the primary cause of the Cushing’s syndrome.